PATfix LNP Switcher Platform
Innovative solution that enables investigation of multiple critical attributes for LNP drug products, without extensive sample preparation or dye requirements.
Place your order directly with the manufacturer.
The PATfix® LNP Switcher Platform is chromatographic system developed to meet the analytical needs of complex lipid nanoparticle (LNP) formulations, including those carrying multiple types of cargo such as mRNA, mcDNA, gRNA, siRNA, or small molecules. It supports fast and comprehensive analysis without requiring dyes or extensive sample preparation—making it well-suited for process development, formulation screening, and post-formulation stability testing.
The system allows for direct analysis of LNP samples through simple dilution, minimizing sample handling while preserving structural integrity. With its sensitive detector combinations of UV, MALS, and others, PATfix® enables the simultaneous assessment of key quality attributes including cargo encapsulation, particle size, integrity, heterogeneity, and purity. Its client-server software architecture supports remote access and collaborative data review, streamlining analytical workflows across teams.
Key Features & Benefits
- Compatible with multi-cargo LNPs (e.g., Cas9 + gRNA)
- Requires only sample dilution—no dyes or pre-treatment needed
- Assesses cargo encapsulation efficiency, heterogeneity, integrity, size, and purity in a single run
- Sensitive detector suite for low sample consumption
- 21 CFR part 11 compliant, remote-access software
Applications
- Characterization of LNPs with single or multiple nucleic acid cargos
- LNP process development and formulation screening
- Post-formulation drug product stability testing
- Analytical support for RNA-based therapeutics and gene therapy products
- Regulatory compliance and reporting
Advancing LNP characterization for drug delivery
Tuesday, October 28 at 16:00 GMT | 17:00 CET | 12:00 EDT | 9:00 PDT
Join experts Prof. Dan Peer from Tel Aviv University | NeoVac Ltd and Tristan Kovačič, Sartorius BIA Separations, as they bring together cutting-edge science and strategic manufacturing insights to explore the full journey of lipid nanoparticles (LNPs), from groundbreaking research to real-world applications.
Prof. Peer will explore the progression and applications of LNPs, from targeting cancer cells to developing the first bacterial mRNA vaccine. He will also discuss personalized medicine using LNPs for precise cell delivery.
Kovačič will complement Peer's work by addressing the complexities of manufacturing and ensuring quality control for LNP-based biopharmaceuticals. He will reveal how advanced analytical techniques, like monolithic chromatography, streamline workflows and guarantee proper handling of diverse cargo formulations critical for in vivo CAR-T, CRISPR and vaccine applications.
This webinar highlights not just the exciting developments in LNP technology but also the critical transition from research to real-world therapeutic applications. Secure your access to insights on cutting-edge LNPs and strategic manufacturing solutions for next-generation medicines.
Who should attend
- Researchers and PhD scientists: Those working in gene therapy, RNA delivery, and nanoparticle pharmaceuticals seeking the latest advancements.
- Formulation scientists: Individuals involved in formulating nucleic acids and lipid nanoparticle technologies.
- Analytical chemists: Experts interested in advanced chromatography techniques for biopharmaceutical characterization.
- Healthcare and medical experts: Those focused on improving the efficacy and safety of biopharmaceuticals for oncological, gene editing and vaccination applications.
- Directors, vice presidents and principal investigators: Innovators in positions of responsibility looking to network and explore collaboration opportunities in biopharmaceuticals.
Certificate of attendance
If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.
Streamlining lipid nanoparticle characterization with a hands-free approach
The RiboGreen assay is a common method for assessing lipid nanoparticle (LNP) encapsulation efficiency, but it is labor-intensive, error-prone, and lacks insight into therapeutic parameters like mRNA integrity.
Mojca Bavčar, Associate Scientist at Sartorius BIA Separations, introduces the PATfix LNP Switcher®, a 2D chromatography system that enables accurate size estimation and encapsulation efficiency analysis. Discover how this instrument can minimize sample preparation by offering a hands-free approach while delivering valuable therapeutic insights, all within a single assay.
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