DynaPro™ NanoStar™ II Dynamic Light Scattering Detector by Waters | Wyatt Technology

The DynaPro™ NanoStar™ II is a unique cuvette-based DLS instrument used for the analysis of proteins, gene therapy vectors, viruses and virus-like particles, promiscuous inhibitors, micelles, liposomes, lipid, and metallic nanoparticles, and more. To accommodate scarce and precious samples, specially designed quartz cuvettes afford robust, accurate measurements with as little as 2 µL of solution, while our proprietary disposable cuvettes provide comparable sensitivity with as little as 4 µL

Walk-up operation with DYNAMICS^® Touch™

The NanoStar is the only DLS instrument to provide a fully integrated, walk-up measurement experience. No need to boot up your lab PC, launch the DLS software, connect to the instrument and worry about where your data files are stored. DYNAMICS Touch is an intuitive—yet capable—DLS measurement app that resides right on the NanoStar. Via the full-size touch screen display, DYNAMICS Touch guides you through the entire setup and measurement process. It tells you if the data quality is sufficient for confidence in the results, and displays them instantly. Data files and concise PDF reports can be stored on the instrument, transferred via the network or downloaded to a flash drive. You can even send the report to your phone!

Features: 

• Sensitivity: 0.1 mg/mL of 14.4 kDa lysozyme
• Hydrodynamic radius (R_h) range: 0.2 – 2500 nm 
• Molar mass range: 300 Da – 1 MDa
• Temperature control: heated/cooled -10 to  +120°C, 
• Minimum sample requirement: 2 µL in quartz microcuvette, 4 µL in disposable microcuvette
• Optional infrared laser wavelength to eliminate fluorescence 
• Can connect via optical fiber to a MALS detector for simultaneous online MALS and DLS measurement with size exclusion chromatography (SEC) or field-flow fractionation (FFF)
• Touch-panel display for immediate access to data, diagnostics and settings
• Software: DYNAMICS^® analysis software offers comprehensive analysis of size and size distributions, molar mass, diffusion interaction parameter kD, second virial coefficient A₂, thermal behavior T_agg/T_m/T_onset, DLS-based viscosity; full export of all results; optional 21CFR11 support for GMP

Applications: 

• Size, aggregation and stability of small molecules, peptides, proteins, vesicles, nanoparticles, quantum dots and low/sub-micron colloids
• Protein quality control for interaction or structural studies
• Protein and polymer weight-average molecular weight
• Macromolecular interactions: diffusion interaction parameter k_D and second virial coefficient A₂ (B₂₂)
• Thermal onset parameters T_agg, T_onset, T_m
• Solubility of polymers
• Critical micelle concentration and temperature
• Nanoparticle structure by combining MALS and DLS sizing